Low birth weight (LBW) (birth weight<2,500 g) is an important public health concern because LBW infants experience higher rates of neonatal morbidity and mortality, stunted growth, infection, feeding difficulties and developmental problems. Whilst improvements in the care of premature and vulnerable babies in hospital have increased survival, there is a transition from hospital to home that is a critical time where mothers and families take on the responsibility for the ongoing care of the baby. Maternal knowledge and skills, confidence, family support, access to health services and continuity of professional guidance have a significant impact on the quality of home-based care. Persistent knowledge-practice gaps can result from mothers' knowledge of recommended newborn care practices, but not being able to apply them consistently due to psychosocial, cultural, socioeconomic or health-system barriers. This review covers maternal education programmes and nurse-led interventions to promote home care of LBW infants and preterm infants. Special emphasis is placed on thermal protection, breastfeeding and feeding support, hygiene and infection prevention, Kangaroo Mother Care (KMC), recognition of neonatal danger signs, growth monitoring, immunization and appropriate health-seeking behaviour. Literature suggests that structured education, skills demonstration, home visits, continuous counselling, family involvement, KMC promotion and digital follow-up can positively impact maternal knowledge and selected caregiving behaviours. But the size and persistence of these impacts can differ significantly depending on the level of interventions, contexts, and the quality of implementation. The interventions of nurses are especially useful as nurses can link the hospital and community care by preparing for discharge, teaching in the practical, home visiting, psychosocial support, referral and follow up. The review highlights that information alone is insufficient to close the knowledge–practice gap. Multimodal education and skills-training, reinforcement, family and community engagement, and system-level support are essential elements of effective interventions. Future studies should focus on standardized outcomes, longer follow-up, more rigorous comparative study designs, cost-effectiveness analysis, and more consideration of family and contextual factors that influence LBW home care.