The concept of precision medicine has evolved as a pioneering approach in modern healthcare. It focuses on a personalized diagnostic system and treatment which is based on individual factors such as genetic factors, lifestyle factors, and environmental factors. The ancient Indian system of Ayurveda is also based on personalized healthcare through the concept of ‘Prakriti’. The phenomenon of Prakriti describes that every individual has a unique constitutional type which is determined by the balance of three doshas - Vata, Pitta, and Kapha. This chapter examines the relationship between ayurvedic prakriti and modern precession medicine. It highlights how the traditional ayurvedic system aligns with modern biology and medicine. Along with this, the chapter integrates traditional Ayurveda with modern systems of medicine. The chapter examines recent studies talking about Ayurgenomics. The chapter also addresses the opportunities and challenges involved in integrating them. The study bridges the Ayurveda and modern biology while contributing to holistic, sustainable, and individual centered healthcare systems.